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  1. Ion channels

    Ion channels are pore-forming protein complexes that facilitate the flow of ions across the hydrophobic core of cell membranes.

    media - 23/05/2014 - 10:20am

  2. Understanding adverse drug reactions and drug allergies: principles, diagnosis and treatment aspects.

    This 22-page open-access article published by Zahra Pourpak et al. in the Journal Recent Patents on Inflammation & Allergy Drug Discovery, describes in detail the WHO definition of adverse drug reactions (ADRs), the common features, classification according to Rawlins and Thompson and beyond. The authors also provide a comprehensive description of predictable Type A, which is dose-related pharmacological effects and the unpredictable, bizarre, Type B hypersensitivity reactions. Tables 1 and 2 detail the common examples of clinical and genetic risks of Type B ADRs.

    efaccena - 12/12/2017 - 10:28am

  3. Antidepressant drugs

    In patients with moderate to severe depression routine antidepressant therapy is effective (as highlighted by Cipriani et al. (2018) following meta-analysis of results from clinical trials of 21 different antidepressants)- and is recommended to be combined with psychological therapy. Drug treatment of mild depression may also be considered in patients with a history of moderate or severe depression.

    smaxwell - 10/10/2014 - 7:55pm

  4. Drugs for HIV infections

    HIV medications are generally classified according to their mechanistic action.

    The main classes are:

    • Nucleoside/Nucleotide Reverse Transcriptase Inhibitors (NRTIs)
    • Non-nucleoside Reverse Transcriptase Inhibitors (NNRTIs)
    • Protease Inhibitors (PIs)
    • Entry (or Fusion) Inhibitors
    • Integrase Inhibitors (or integrase strand transfer inhibitors (INSTIs))
    • Attachment Inhibitors
    • Capsid Inhibitors

     

    Nucleoside/Nucleotide Reverse Transcriptase Inhibitors (NRTIs)

    efaccena - 29/08/2016 - 11:15am

  5. Lipid-lowering drugs

    There are several classes of established lipid-lowering, or antihyperlipidemic drugs available to the prescriber.

    The choice of which agent to use depends greatly on the patient's cholesterol profile, cardiovascular, liver and kidney function.

    smaxwell - 10/10/2014 - 9:16am

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