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  1. Immuno-oncology

    Immune Checkpoint inhibitors

    efaccena - 06/09/2022 - 2:03pm

  2. Cardiovascular peptides

    Many vasoactive peptides are implicated in vascular (patho)biology.

    efaccena - 07/03/2016 - 2:07pm

  3. Other ion channels

    Other ion channel families include the aquaporins (which also includes aquaglyceroporins), a family of chloride channels which includes the cystic fibrosis transmembrane conductance regulator (CFTR), the connexins and pannexins

    efaccena - 01/03/2016 - 10:15am

  4. PARP inhibitors

    Poly(ADP-ribose) polymerase (PARP) inhibitors

    efaccena - 03/02/2023 - 10:11am

  5. Other autacoids

    The pharmacology and clinical impact of histamine and serotonin have been described above. This section will focus on other clinically important autacoid molecules.

    Autacoids release can be triggered by agents including chemical and immune irritants, UV light, bacterial toxins and physical trauma.

    Whilst histamine mediates the wheal, flare and redness reactions, the prostaglandins mediate pain.

    efaccena - 29/03/2016 - 1:12pm

  6. Migraine

    Migraine is a complex condition, but it is characterised as a moderate to severe, pulsating headache that is typically unilateral, and is often accompanied by nausea and disturbed vision (aura). Migraines can last from two hours to several days. Associated symptoms can include nausea and vomiting, as well as sensitivities to light, sound or smell.

    Medical intervention is indicated when the migraines become frequent and/or are severe.

    efaccena - 22/05/2018 - 11:51am

  7. HIV

    HIV type 1 (HIV-1, HIV) infects CD4+ T cells of the immune system, via interactions with CD4 on T cell membranes and with the co-receptors CXCR4 and CCR5, which are two chemokine GPCRs. Once inside the cell the HIV genome is inserted into the host genome and hijacks the host transcriptional and translational machinery to replicate new viral particles. HIV infection ultimately leads to destruction of CD4+ T cells as the T cells lyse and release new virus, which go on to infect and destroy more T cells.

    efaccena - 11/08/2017 - 9:05am

  8. Transporters as drug targets, and drug interactions

    Monoamine reuptake transporters

    efaccena - 21/03/2016 - 1:57pm

  9. Histamine

    Histamine is a vasoactive amine (a.k.a. a biogenic amine). It acts via a family of G protein-coupled receptors (histamine receptors H1-H4). The histamine receptors are differentially expressed, and couple to different second messenger systems. This results in context-specific effects in response to histamine release.

    efaccena - 30/03/2016 - 9:21am

  10. Antiplatelet drugs

    Antiplatelet drugs are designed to decrease platelet aggregation to inhibit thrombus formation in the arterial circulation. Used to treat patients with cardiac and cerebrovascular conditions.

    They are classified according to their mechanism of action:

    smaxwell - 10/10/2014 - 9:12am

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