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Immuno-oncology
Immune Checkpoint inhibitors
efaccena - 06/09/2022 - 2:03pm
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Cardiovascular peptides
Many vasoactive peptides are implicated in vascular (patho)biology.
efaccena - 07/03/2016 - 2:07pm
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Other ion channels
Other ion channel families include the aquaporins (which also includes aquaglyceroporins), a family of chloride channels which includes the cystic fibrosis transmembrane conductance regulator (CFTR), the connexins and pannexins
efaccena - 01/03/2016 - 10:15am
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PARP inhibitors
Poly(ADP-ribose) polymerase (PARP) inhibitors
efaccena - 03/02/2023 - 10:11am
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Other autacoids
The pharmacology and clinical impact of histamine and serotonin have been described above. This section will focus on other clinically important autacoid molecules.
Autacoids release can be triggered by agents including chemical and immune irritants, UV light, bacterial toxins and physical trauma.
Whilst histamine mediates the wheal, flare and redness reactions, the prostaglandins mediate pain.
efaccena - 29/03/2016 - 1:12pm
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Migraine
Migraine is a complex condition, but it is characterised as a moderate to severe, pulsating headache that is typically unilateral, and is often accompanied by nausea and disturbed vision (aura). Migraines can last from two hours to several days. Associated symptoms can include nausea and vomiting, as well as sensitivities to light, sound or smell.
Medical intervention is indicated when the migraines become frequent and/or are severe.
efaccena - 22/05/2018 - 11:51am
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HIV
HIV type 1 (HIV-1, HIV) infects CD4+ T cells of the immune system, via interactions with CD4 on T cell membranes and with the co-receptors CXCR4 and CCR5, which are two chemokine GPCRs. Once inside the cell the HIV genome is inserted into the host genome and hijacks the host transcriptional and translational machinery to replicate new viral particles. HIV infection ultimately leads to destruction of CD4+ T cells as the T cells lyse and release new virus, which go on to infect and destroy more T cells.
efaccena - 11/08/2017 - 9:05am
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Transporters as drug targets, and drug interactions
Monoamine reuptake transporters
efaccena - 21/03/2016 - 1:57pm
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Histamine
Histamine is a vasoactive amine (a.k.a. a biogenic amine). It acts via a family of G protein-coupled receptors (histamine receptors H1-H4). The histamine receptors are differentially expressed, and couple to different second messenger systems. This results in context-specific effects in response to histamine release.
efaccena - 30/03/2016 - 9:21am
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Antiplatelet drugs
Antiplatelet drugs are designed to decrease platelet aggregation to inhibit thrombus formation in the arterial circulation. Used to treat patients with cardiac and cerebrovascular conditions.
They are classified according to their mechanism of action:
smaxwell - 10/10/2014 - 9:12am