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  1. Drugs for HIV infections

    HIV medications are generally classified according to their mechanistic action.

    The main classes are:

    • Nucleoside/Nucleotide Reverse Transcriptase Inhibitors (NRTIs)
    • Non-nucleoside Reverse Transcriptase Inhibitors (NNRTIs)
    • Protease Inhibitors (PIs)
    • Entry (or Fusion) Inhibitors
    • Integrase Inhibitors (or integrase strand transfer inhibitors (INSTIs))
    • Attachment Inhibitors
    • Capsid Inhibitors


    Nucleoside/Nucleotide Reverse Transcriptase Inhibitors (NRTIs)

    efaccena - 29/08/2016 - 11:15am

  2. HIV

    HIV type 1 (HIV-1, HIV) infects CD4+ T cells of the immune system, via interactions with CD4 on T cell membranes and with the co-receptors CXCR4 and CCR5, which are two chemokine GPCRs. Once inside the cell the HIV genome is inserted into the host genome and hijacks the host transcriptional and translational machinery to replicate new viral particles. HIV infection ultimately leads to destruction of CD4+ T cells as the T cells lyse and release new virus, which go on to infect and destroy more T cells.

    efaccena - 11/08/2017 - 9:05am