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  1. Tubulin and microtubules as targets for anticancer drugs

    Cytoskeletal targeting compounds are small molecules that interact with actin or tubulin. They can either

    • stabilise cytoskeletal components
    • prevent polymerisation of monomers into filaments
    • enhance de-polymerisation of already formed filaments

    Actin-targeting compounds have not been transferred to the clinic, but are useful experimental tools used to further understanding of how the actin machinery in cells works.

    efaccena - 21/03/2016 - 1:52pm

  2. Mitotic spindle poisons

    Mechanism of action

    efaccena - 30/03/2023 - 2:01pm

  3. Transporters as drug targets, and drug interactions

    Monoamine reuptake transporters

    efaccena - 21/03/2016 - 1:57pm