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  1. Heart failure

    Heart failure (HF) is caused by the heart’s inability to pump enough blood to meet the body’s needs. In response, the body activates compensatory mechanisms, such as the sympathetic nervous system which leads to tachycardia, sodium and water retention, vasoconstriction, and over time, ventricular hypertrophy, all geared towards increasing cardiac output. Leading causes of HF are coronary artery disease and hypertension.

    efaccena - 11/03/2019 - 11:56am

  2. Angiotensin receptor antagonists

    Angiotensin receptor antagonists are used to treat hypertension, diabetic nephropathy and congestive heart failure. As a group these drugs are termed 'sartans', and this forms the stem of their non-proprietary names.

    smaxwell - 10/10/2014 - 9:07am

  3. Cardiovascular peptides

    Many vasoactive peptides are implicated in vascular (patho)biology.

    efaccena - 07/03/2016 - 2:07pm

  4. Hypertension

    Elevated blood pressure (BP) is the product of increased cardiac output (CO) and peripheral vascular resistance (PVR). Increased CO may result from increased fluid volume from excess sodium intake or renal sodium retention, stimulation of the renin-angiotensin-aldosterone system (RAAS), or activation of the sympathetic nervous system (SNS). Functional constriction or structural hypertrophy of the vasculature increases PVR. Both result from excess stimulation of the RAAS, SNS overactivity, genetic alterations of cell membranes, or endothelial-derived factors.

    efaccena - 06/05/2019 - 1:49pm

  5. Calcium channel blocking drugs

    Calcium-channel blockers (CCBs) are prescribed to treat hypertension. These drugs interfere with the inward movement of calcium ions through the slow channels on the membranes of myocardial cells, AV node cells and vascular smooth muscle cells. The overall effect is to reduce myocardial contractility, formation and propagation of electrical impulses within the heart, and vascular tone.

    There is a wide variety of CCB medications available to prescribers, including single agent medicines and fixed-dose combination drugs.

    smaxwell - 10/10/2014 - 9:08am