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  1. Drugs affecting acetylcholine receptors

    Drugs acting at ganglion nicotinic receptors

    As the same receptors are present at the ganglia of both the sympathetic and parasympathetic arms of the ANS, they cannot be differentiated pharmacologically.  Being ionotropic receptors, overstimulation can lead to depolarization blockade.  Thus, there is the potential for both agonists and antagonists to inhibit ganglionic neurotransmission.  Although ganglion blocking drugs have been used in the past in the treatment of hypertension, they are now considered clinically obsolete.

    efaccena - 21/03/2016 - 10:49am