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Diuretics
Diuretics are particularly useful in treating the water and salt retention caused by heart failure.
Common side effects like muscle cramps arise from the loss of too much sodium, potassium or magnesium. Prescribers should be aware of the risk of diuretic-induced hypokalaemia.
There are three main types of diuretic, each of which works by affecting a different part of the kidneys:
Loop diuretics- prescribed for fluid retention (oedema), particularly in the lungs. These drugs are very fast acting, but of short duration and induce dramatic water loss.
smaxwell - 10/10/2014 - 9:03am
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Ligand-gated ion channels
Ligand-gated ion channels (LGICs) mediate passive ion flux driven by the electrochemical gradient for the permeant ions. LGICs are gated by the binding of a specific ligand to an orthosteric site(s) that triggers a conformational change that results in the conducting state, or by binding of endogenous, or exogenous, modulators to allosteric sites. LGICs are responsible for fast synaptic transmission in the nervous system and at the somatic neuromuscular junction.
efaccena - 24/02/2016 - 3:56pm