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  1. Angiotensin receptor antagonists

    Angiotensin receptor antagonists are used to treat hypertension, diabetic nephropathy and congestive heart failure. As a group these drugs are termed 'sartans', and this forms the stem of their non-proprietary names.

    smaxwell - 10/10/2014 - 9:07am

  2. Cardiovascular peptides

    Many vasoactive peptides are implicated in vascular (patho)biology.

    efaccena - 07/03/2016 - 2:07pm

  3. Hypertension

    Elevated blood pressure (BP) is the product of increased cardiac output (CO) and peripheral vascular resistance (PVR). Increased CO may result from increased fluid volume from excess sodium intake or renal sodium retention, stimulation of the renin-angiotensin-aldosterone system (RAAS), or activation of the sympathetic nervous system (SNS). Functional constriction or structural hypertrophy of the vasculature increases PVR. Both result from excess stimulation of the RAAS, SNS overactivity, genetic alterations of cell membranes, or endothelial-derived factors.

    efaccena - 06/05/2019 - 1:49pm