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  1. Phosphodiesterase inhibitors

    Phosphodiesterases (PDEs) are enzymes responsible for the inactivation of the intracellular second messengers cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). There are many subtypes of phosphodiesterases and many inhibitors which can be either non-specific, or selective in their inhibitory profile.

    efaccena - 08/03/2016 - 9:19am

  2. Chronic obstructive pulmonary disease (COPD)

    COPD is a largely preventable lung condition. The main risk factor for development and exacerbation of COPD is tobacco smoking, but environmental and/or occupational exposure to pollutants is also implicated in the pathology of COPD. A very small number of cases are caused by genetic defects or impaired lung development. Smoking cessation is the most effective way to prevent COPD, or to reduce symptoms and exacerbations from established disease.

    efaccena - 03/03/2023 - 9:36am