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  1. Acute ischemic stroke (AIS)

    Acute ischemic stroke is caused by thrombotic or embolic occlusion of a cerebral artery, which leads to a sudden loss of blood circulation to a focal area of the brain. This results in a corresponding loss of neurologic function. The text that follows has been summarized and adapted from a transcript written by Amanda Dippold as part of her clinical pharmacology training.

    efaccena - 14/08/2018 - 10:32am

  2. Anticoagulant drugs

    Anticoagulants are used to prevent the formation or growth of fibrin/erythrocyte thrombi in the venous circulation. They are not useful for treating arterial thrombi which are mainly composed of platelet aggregates.

    Anticoagulants can be administered parenterally or orally.

    smaxwell - 10/10/2014 - 9:11am

  3. Venous thromboembolism

    Venous thromboembolism (VTE) is a blood clot in a vein. VTEs can partially or completely obstruct blood flow. The most frequent types of VTE are

    • deep-vein thrombosis (DVT) and
    • pulmonary embolism (PE)

    Pharmacological VTE prophylaxis and treatment relies on the use of different classes of drugs; anti-coagulants, antiplatelet drugs and thrombolytic/fibrinolytic agents.

    efaccena - 18/04/2023 - 2:18pm

  4. Arrhythmias

    The normal heart beats regularly at 60–100 beats per min (bpm), which is controlled by the sinoatrial (SA) node located in the right atrium. Tachycardia describes a heart that beats more rapidly (>100 bpm). Bradycardia describes a situation where the heart beats more slowly (<60 bpm). Electrical signals generated in the SA node travel through a conduction pathway in the wall of the atria (causing atrial contraction) before reaching and depolarising the AV node.

    efaccena - 15/03/2022 - 12:40pm