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  1. Drugs for viral hepatitis- HBV and HCV

    Hepatitis B

    Hepatitis B is an infectious disease caused by the hepatitis B virus (HBV). It can cause both acute and chronic infections. Most cases of chronic disease are asymptomatic, however, cirrhosis and liver cancer may eventually develop. HBV is transmitted by exposure to infectious blood or body fluids. The infection can be diagnosed 30 to 60 days after exposure. HBV infection has been preventable by vaccination since 1982, with two or three doses required to achieve full protection. Natural life-long resistance develops following infection.

    efaccena - 29/08/2016 - 11:17am

  2. Drugs for HIV infections

    HIV medications are generally classified according to their mechanistic action.

    The main classes are:

    • Nucleoside/Nucleotide Reverse Transcriptase Inhibitors (NRTIs)
    • Non-nucleoside Reverse Transcriptase Inhibitors (NNRTIs)
    • Protease Inhibitors (PIs)
    • Entry (or Fusion) Inhibitors
    • Integrase Inhibitors (or integrase strand transfer inhibitors (INSTIs))
    • Attachment Inhibitors
    • Capsid Inhibitors

     

    Nucleoside/Nucleotide Reverse Transcriptase Inhibitors (NRTIs)

    efaccena - 29/08/2016 - 11:15am

  3. HIV

    HIV type 1 (HIV-1, HIV) infects CD4+ T cells of the immune system, via interactions with CD4 on T cell membranes and with the co-receptors CXCR4 and CCR5, which are two chemokine GPCRs. Once inside the cell the HIV genome is inserted into the host genome and hijacks the host transcriptional and translational machinery to replicate new viral particles. HIV infection ultimately leads to destruction of CD4+ T cells as the T cells lyse and release new virus, which go on to infect and destroy more T cells.

    efaccena - 11/08/2017 - 9:05am

  4. Viral hepatitis

    There are five known hepatitis viruses: A, B, C, D, and E. All cause disease which primarily affect the liver.

    Hepatitis A

    efaccena - 20/02/2018 - 2:36pm

  5. Transporters as drug targets, and drug interactions

    Monoamine reuptake transporters

    efaccena - 21/03/2016 - 1:57pm

  6. Drugs for SARS-CoV-2 infection (COVID-19)

    COVID-19 is the disease caused by infection by SARS-CoV-2 (severe acute respiratory syndrome virus 2), the airbourne, respiratory coronavirus that was first detected in China’s city of Wuhan in late 2019. The spread of this virus rapidly became a global pandemic that has resulted in millions of deaths. The pace of the subsequent response by the medical, pharmacology, scientific and pharmaceutical research communities has been unprecedented and delvered significant advances in both vaccinations and therapeutic interventions.

    efaccena - 05/04/2022 - 11:39am