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  1. Constipation (chronic)

    Chronic constipation can be idiopathic (with an unknown cause or mechanism) or can be caused by aetiologies that include systemic disorders and drug-induced constipation (a very common side-effect of long-term opiate use). Idiopathic Chronic constipation is often associated with normal or slow colonic transit and/or defecatory dysfunction.

    The choice of treatment depends on the cause of the condition. Effective management will normally include a range of interventions, not drug treatments alone.

    efaccena - 09/02/2023 - 1:45pm

  2. Laxative drugs

    Laxatives are used to treat constipation (defined as passing hard stools less frequently than normal for the patient). The aetiology of constipation is varied and can be a symptom of organic disease, or can be a side effect of certain drug treatments (e.g. opioid-induced constipation, OIC). Laxatives are of clinical value in the treatment of irritable bowel syndrome (IBS), OIC, as part of anthelmintic treatment or to clear the alimentary tract before surgery and radiological procedures. Abuse of laxatives may lead to hypokalaemia.

    smaxwell - 10/10/2014 - 9:02am

  3. Drugs affecting cholinergic neurotransmission

    Drugs affecting synthesis, storage or release of acetylcholine

    efaccena - 21/03/2016 - 10:38am