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1. Renal osteodystrophy (bone disease)

   Bone health is regulated by several inter-connected pathways:

   efaccena - 29/05/2023 - 2:03pm

2. Bone resorption inhibitors

   Bisphosphonates

   Bisphosphonates are a class of drugs used to prevent loss of bone mass in conditions characterised by excessive bone resorption which causes bone fragility, such as osteoporosis, Paget's disease of bone, bone metastasis and primary hyperparathyroidism. Mechanistically bisphosphonates bind to hydroxyapatite on bony surfaces, and are taken in to osteoclasts during bone resorption. Bisphosphonates act to disrupt osteoclast function and number (via apoptosis).

   efaccena - 22/07/2016 - 8:27am

3. Endocrine peptides

   Endocrine peptides are the proteinaceous subset of the hormones produced by the glands of the endocrine system. The major endocrine glands include the pineal gland, pituitary gland, pancreas, ovaries, testes, thyroid gland, parathyroid gland, hypothalamus, gastrointestinal tract and adrenal glands. Endocrine hormones regulate a vast array of bodily functions including metabolism, growth and development, tissue function, sexual function, reproduction, sleep, and mood.

   efaccena - 07/03/2016 - 2:09pm