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1. Local anaesthetics

   Local anaesthetics (LAs) are applied to block nociception (pain perception) that is transmitted via peripheral Aδ and C nerve fibres to the brain. Chemically, LAs are amphiphilic molecules with a hydrophobic aromatic group and a basic amine group. They are weak bases that act in their ionised form, but which can only diffuse across the cell membrane to their site of action (at the intracellular face of voltage-gated sodium channels) in their un-ionised form.

   efaccena - 11/03/2019 - 12:46pm