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1. Drug interactions - Excretion

   Excretion interactions primarily involve changes in renal excretion. This might be due to drug-induced reduction in glomerular filtration rate (e.g. diuretic-induced dehydration, ACE inhibitors, NSAIDs). This can reduce the clearance and increase the plasma concentration of many drugs, including some with a low therapeutic index (e.g. digoxin, lithium, aminoglycoside antibiotics). Less commonly, interactions may be due to competition for a common tubular organic anion transporters (e.g. methotrexate excretion may be inhibited by competition with NSAIDs).

   smaxwell - 30/12/2015 - 10:33am

2. Transporters as drug targets, and drug interactions

   Monoamine reuptake transporters

   efaccena - 21/03/2016 - 1:57pm