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  1. Drug metabolizing enzymes

    Cytochrome P450 enzymes are the main drug metabolising enzymes (xenobiotic inactivators) in humans, and these are the primary contributors to Phase I oxidative metabolism of drugs and other chemicals.

    efaccena - 08/03/2016 - 9:21am

  2. Kinase inhibitors

    Protein and (lipid kinases) represent an important target class for treating human disorders, as their aberrant activity underlies a variety of pathologies, ranging from cancer, inflammatory diseases, diabetes, infectious diseases, and cardiovascular disorders.

    efaccena - 08/03/2016 - 1:38pm

  3. Breast Cancer: HER2 (ERBB2) targeting therapies

    HER2 (encoded by the ERBB2 gene) is a tyrosine kinase that is one of the receptors for EGF (epidermal growth factor). HER2 is often mutated in tumors (approximately one quarter of breast cancers, for example), and mutant HER2's dysregulated activity drives several pathways that promote cancer cell phenotypes. Among the most studied downstream pathways that are activated by EGF are the MAPK and PI3K/Akt pathways. Mutations in the HER2 protein (referred to has HER2v here) are associated with poor prognosis. There are essentially two approaches for targeting HER2v positive cancers

    efaccena - 11/04/2023 - 2:44pm