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  1. Mitotic spindle poisons

    Mechanism of action

    efaccena - 30/03/2023 - 2:01pm

  2. Tubulin and microtubules as targets for anticancer drugs

    Cytoskeletal targeting compounds are small molecules that interact with actin or tubulin. They can either

    • stabilise cytoskeletal components
    • prevent polymerisation of monomers into filaments
    • enhance de-polymerisation of already formed filaments

    Actin-targeting compounds have not been transferred to the clinic, but are useful experimental tools used to further understanding of how the actin machinery in cells works.

    efaccena - 21/03/2016 - 1:52pm

  3. Drug metabolizing enzymes

    Cytochrome P450 enzymes are the main drug metabolising enzymes (xenobiotic inactivators) in humans, and these are the primary contributors to Phase I oxidative metabolism of drugs and other chemicals.

    efaccena - 08/03/2016 - 9:21am