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  1. Drugs affecting synthesis, storage, release or removal of noradrenaline

    Drugs which affect the synthesis or storage of noradrenaline will affect all sympathetic nerves, thereby causing a diverse range of effects.  In addition, because there is an overlap in the mechanisms involved in the synthesis, storage, release and removal of noradrenaline, adrenaline and dopamine, drugs which affect noradrenergic neurotransmission will

    hbenson - 24/06/2015 - 1:39pm

  2. The Sympathetic Nervous System

    The sympathetic nervous (adrenergic) system:

    Drugs can modulate the activity of the sympathetic nervous system by affecting the synthesis, storage, release or reuptake of noradrenaline, or its interaction with adrenoceptors.

    media - 23/05/2014 - 10:22am

  3. Positive inotropic drugs: Catecholamines and PDE3 inhibitors

    Positive inotropic agents increase myocardial contractility by increasing the level of calcium in the cytoplasm of the muscle cells or by increasing the sensitivity of the heart to calcium. Positive inotropes are indicated in acute conditions where there is low cardiac output (CO), such as cardiogenic shock following myocardial infarction, acute decompensated heart failure, low CO states after cardiac surgery, cardiogenic shock, septic shock, and cardiomyopathy. In contrast, negative inotropes weaken the force of contraction of the heart

    smaxwell - 10/10/2014 - 9:03am

  4. ANS Part II: Receptors, transmitters and drugs

    The two principal (or 'classical') small transmitter molecules used by neurons of the motor ANS are acetylcholine (ACh) and noradrenaline (NA).

    efaccena - 01/09/2017 - 10:39am

  5. Neurotransmitters

    Synaptic transmission relies on local synthesis, and release of neurotransmitter molecules at the synapse, binding of the neurotransmitter to its cognate post-synaptic receptor(s) and inactivation/removal of the neurotransmitter from the synaptic space to terminate the activation.

    efaccena - 29/03/2016 - 1:09pm

  6. Antidepressant drugs

    In patients with moderate to severe depression routine antidepressant therapy is effective (as highlighted by Cipriani et al. (2018) following meta-analysis of results from clinical trials of 21 different antidepressants)- and is recommended to be combined with psychological therapy. Drug treatment of mild depression may also be considered in patients with a history of moderate or severe depression.

    smaxwell - 10/10/2014 - 7:55pm

  7. Sympathetic nerve endings animation

    An animation that illustrates the synthesis, storage and release of noradrenaline from sympathetic nerve endings.

    hbenson - 24/06/2015 - 2:46pm

  8. Receptor selectivity

    Receptors are named on the basis of their major endogenous agonist (e.g. adrenergic, serotoninergic, opioid). They are then usually ‘sub-­‐typed’ on the basis of their selectivity for agonists or antagonists. Agonist selectivity is determined by the ratio of EC50 of the dose– response curve at the two different receptor subtypes. For example, β-­‐adrenoceptors can be sub-­‐typed into β1 and β2, on the basis of their responsiveness to the endogenous agonist, noradrenaline.

    efaccena - 20/11/2015 - 11:28am

  9. The Autonomic Nervous System

    This 23 slide Powerpoint presentation is intended to introduce the reader to the function of the autonomic nervous system (ANS). Specific areas that are covered include: the basic organization of the motor ANS and its components; the sympathetic and parasympathetic outflows from the central nervous system (CNS) to peripheral organs: the basics of neurochemical neurotransmission within the motor ANS including key neurotransmitters and receptor types; important selected activities of the motor ANS and finally some misconceptions regarding the ANS that even the beginner should be aware of.

    efaccena - 01/09/2017 - 1:57pm

  10. Beta-adrenoceptor blocking drugs

    Beta blockers, also known as beta-adrenoceptor blocking agents, are pharmaceutical agents that act as competitive antagonists of the β-adrenoceptors, which are activated by the endogenous catecholamines epinephrine (adrenaline) and norepinephrine (noradrenaline), of the sympathetic nervous system.

    smaxwell - 10/10/2014 - 9:04am