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GPCRs: Opioid receptors
RECEPTOR
GENE
TISSUE EXPRESSION
G PROTEIN TRANSDUCER/INTRACELLULAR RESPONSE
ENDOGENOUS LIGANDS
OPRM1
efaccena - 30/10/2023 - 3:17pm
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Opioid misuse
Opioid drugs (e.g. morphine) are derived from a naturally occurring substance extracted from the seed pod of the Asian opium poppy plant.
smaxwell - 21/06/2016 - 10:55am
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Opioid analgesics
Many opiod analgesics are available to the prescriber.
smaxwell - 10/10/2014 - 7:51pm
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Drug metabolism
The primary objective of drug metabolism is to facilitate a drug’s excretion by increasing its water solubility (hydrophilicity). The involved chemical modifications incidentally decrease or increase a drug’s pharmacological activity and/or half-life, the most extreme example being the metabolic activation of inactive prodrugs into active drugs, e.g.
media - 23/05/2014 - 10:25am
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Mechanisms of analgesia 2017_2018
This set of 17 slides introduces students (beginner to intermediate learners) to some of the basic physiological processes that are the targets of many analgesic drug classes. Specific areas covered include the regulation of nociceptive input to the spinal cord by processes within the superficial layers of the cord itself and also descending fibres from the brainstem.
efaccena - 11/07/2018 - 9:05am
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Agonists, antagonists, and partial agonists
Receptor ligands can be distinguished on the basis of their potential to initiate a biological response following receptor binding:
efaccena - 18/11/2015 - 3:20pm