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  1. Antihyperglycemics (1)- oral

    Antihyperglycemic medications are used for glycemic control. Maintaining appropriate blood glucose levels in patients with hyperglycemia is important for minimizing the risk of acute symptoms, long-term complications, and mortality. There are many physiological causes of hyperglycemia, so multi-drug regimens may be required to control blood glucose levels.

    Currently, there are 7 classes of oral antihyperglycemics.

    efaccena - 14/01/2019 - 10:42am

  2. Therapy optimization

    Patients with a given disease may differ dramatically in the desired and undesired effects of one and the same standard drug therapy. Extreme examples are:

    efaccena - 24/03/2016 - 9:43am

  3. Phases of drug metabolism

    The usual classification of drug metabolism enzymes and reactions as Phase I or II is somewhat misleading, as these reactions affect some drugs in a reverse order (Phase II followed by Phase I, e.g. isoniazid) or separately (Phase I or Phase II). Type I and II would be therefore more appropriate. Note that some drugs (e.g. metformin) are not metabolized at all.   

    efaccena - 01/03/2016 - 1:03pm

  4. Transporters as drug targets, and drug interactions

    Monoamine reuptake transporters

    efaccena - 21/03/2016 - 1:57pm