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1. Alkylating chemotherapy agents

   Alkylating agents were one of the earliest classes of drugs used to treat cancer. They disrupt DNA structure and formation to cause irreparable DNA damage in cancer cells which ultimately leads to cell death.

   The five major categories of alkylating agents are:

   efaccena - 21/03/2016 - 3:36pm

2. alkylating agent

   Agents that damage DNA and prevent cells from proliferating; used to treat many different cancers. classical antineoplastic alkylating agents are melphalan and chlorambucil.

   efaccena - 02/12/2022 - 3:07pm

3. Alkylating Agents: Nitrogen mustard derivatives

   Several alkylating agents are used in clinical practice. They all share the same mechanism of action; they introduce alkyl groups into nucleophilic sites on other molecules, DNA being the principal target in cancers.  Alkylating agents can be subdivided into chemical classes, one of which is the nitrogen mustard derivatives.

   

   efaccena - 16/03/2023 - 12:36pm