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NSAIDs for musculoskeletal conditions
There are about 20 different nonsteroidal anti-inflammatory drugs (NSAIDs) available. Some, such as aspirin and ibuprofen, are widely available over-the-counter (OTC). Others are only available on prescription. NSAIDs are the most frequently used medicines for symptomatic relief in osteoarthritis (OA), the most common form of arthritis, and are often prescribed to rheumatoid arthritis (RA) patients.
efaccena - 22/07/2016 - 8:25am
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NSAIDs (inflammation)
NSAIDs have historically been classified according to their chemical composition, but as mechanism of action has come to the fore, this is also used to classify these drugs.
NSAIDs within classes have similar characteristics and tolerability, with little difference in clinical efficacy at equivalent doses. The prescribers’ choice will be determined by other factors such as dosing regimens, route of administration and tolerability. For example, ibuprofen and diclofenac have half-lives of just 2–3 hours, whereas the oxicams have half-lives 10 times longer.
efaccena - 09/09/2016 - 9:27am
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Locomotor system
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media - 23/05/2014 - 11:09am
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Cyclooxygenase (COX) inhibitors
Cyclooxygenase (COX) inhibitors are non-steroidal anti-inflammatory drugs (NSAIDs), used clinically to relieve fever and pain, such as those associated with headaches, colds, flu, and arthritis. NSAIDs are available by prescription and over-the-counter (OTC).
efaccena - 08/03/2016 - 9:19am
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Mood stabilising drugs
A variety of chemotypes are grouped together as the mood stabilising drugs, used in the management of bipolar disorder (manic depression), mania and hypomania, and sometimes recurrent severe depression. Naming these drugs as mood stabilisers belies their action of stabilising mood in patients who experience problems with extreme highs, extreme lows, or mood swings between extreme highs and lows.
Mood stabilisers should only be prescribed by mental health professionals, such as psychiatrists.
smaxwell - 10/10/2014 - 7:56pm
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Sickle cell disease
Sickle cell anaemia is a potentially life-threatening genetic condition that is caused by inheritance of genes that encode abnormal beta-globin proteins. The sickle haemoglobin (or HbS) variant produces haemoglobin that polymerises into a distorted conformation when in the deoxygenated state. This results in erythrocyte deformation into the classic sickle shape. A sickle cell crisis ensues when the misshapen and rigid erythrocytes form clumps that block blood vessels.
efaccena - 15/02/2023 - 12:05pm