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Antipsychotic drugs
Antipsychotic use is associated with significant side-effects, most notably movement disorders (tardive dyskinesia) and weight gain. It is unclear whether the atypical (second-generation) antipsychotics offer advantages over older, first generation antipsychotics. Drop-out and symptom relapse rates are similar for both classes of drugs.
Both generations of medication block receptors in the brain's dopamine pathways, but atypical antipsychotics often act on serotonin receptors as well.
smaxwell - 10/10/2014 - 7:56pm
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Overview of types of receptors, their mechanisms of action and examples
Main types of drug targets and their mechanisms of action
Drug Target
Description
Example(s)
Receptors
media - 22/05/2014 - 12:09pm
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Antidepressant drugs
In patients with moderate to severe depression routine antidepressant therapy is effective (as highlighted by Cipriani et al. (2018) following meta-analysis of results from clinical trials of 21 different antidepressants)- and is recommended to be combined with psychological therapy. Drug treatment of mild depression may also be considered in patients with a history of moderate or severe depression.
smaxwell - 10/10/2014 - 7:55pm
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Depression
Depression (major depressive disorder) is a mood disorder characterised by low mood which persists for weeks or months and has a significant impact on daily life. It is a common disorder and the WHO estimates that around 5% of adults globally are affected.
Aetiology
efaccena - 05/06/2023 - 12:55pm