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Calcium channel blocking drugs
Calcium-channel blockers (CCBs) are prescribed to treat hypertension. These drugs interfere with the inward movement of calcium ions through the slow channels on the membranes of myocardial cells, AV node cells and vascular smooth muscle cells. The overall effect is to reduce myocardial contractility, formation and propagation of electrical impulses within the heart, and vascular tone.
There is a wide variety of CCB medications available to prescribers, including single agent medicines and fixed-dose combination drugs.
smaxwell - 10/10/2014 - 9:08am
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Voltage-gated ion channels
Voltage-gated ion channels (VGICs) are responsive to changes in the local electrical membrane potential, and are critical for the function of excitable cells, such as neurons and muscle cells. VGICs are ion-selective, with separate channels identified for each of the major physiological ions- Na+, K+, Ca2+, Cl-. Each type of channel is a multimeric complex of subunits encoded by a number of genes. Subunit combinations vary in different tissues, with each combination having distinctive voltage dependence and cellular localization.
efaccena - 24/02/2016 - 3:26pm