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  1. Cardiovascular peptides

    Many vasoactive peptides are implicated in vascular (patho)biology.

    efaccena - 07/03/2016 - 2:07pm

  2. Gasotransmitters

    There are many gaseous chemicals with effects/functions in the human body, however only three of these act as bona fide 'gasotransmitters' (or gaseous transmitters): nitric oxide (NO, a free-radical mediator), carbon monoxide (CO) and hydrogen sulfide (H2S). These three regulate a variety of key biological functions and are also implicated in tumour biology. They can have endocrine, paracrine, and autocrine actions. They are produced enzymatically under tight regulation. They have varying biological half-lives, which affects their mode of transmitter action.

    efaccena - 29/03/2016 - 1:08pm

  3. PARP inhibitors

    Poly(ADP-ribose) polymerase (PARP) inhibitors

    efaccena - 03/02/2023 - 10:11am

  4. Other autacoids

    The pharmacology and clinical impact of histamine and serotonin have been described above. This section will focus on other clinically important autacoid molecules.

    Autacoids release can be triggered by agents including chemical and immune irritants, UV light, bacterial toxins and physical trauma.

    Whilst histamine mediates the wheal, flare and redness reactions, the prostaglandins mediate pain.

    efaccena - 29/03/2016 - 1:12pm

  5. Antidepressant drugs

    In patients with moderate to severe depression routine antidepressant therapy is effective (as highlighted by Cipriani et al. (2018) following meta-analysis of results from clinical trials of 21 different antidepressants)- and is recommended to be combined with psychological therapy. Drug treatment of mild depression may also be considered in patients with a history of moderate or severe depression.

    smaxwell - 10/10/2014 - 7:55pm

  6. Other ion channels

    Other ion channel families include the aquaporins (which also includes aquaglyceroporins), a family of chloride channels which includes the cystic fibrosis transmembrane conductance regulator (CFTR), the connexins and pannexins

    efaccena - 01/03/2016 - 10:15am

  7. Histamine

    Histamine is a vasoactive amine (a.k.a. a biogenic amine). It acts via a family of G protein-coupled receptors (histamine receptors H1-H4). The histamine receptors are differentially expressed, and couple to different second messenger systems. This results in context-specific effects in response to histamine release.

    efaccena - 30/03/2016 - 9:21am

  8. Ion channels

    Ion channels are pore-forming protein complexes that facilitate the flow of ions across the hydrophobic core of cell membranes.

    media - 23/05/2014 - 10:20am

  9. Migraine

    Migraine is a complex condition, but it is characterised as a moderate to severe, pulsating headache that is typically unilateral, and is often accompanied by nausea and disturbed vision (aura). Migraines can last from two hours to several days. Associated symptoms can include nausea and vomiting, as well as sensitivities to light, sound or smell.

    Medical intervention is indicated when the migraines become frequent and/or are severe.

    efaccena - 22/05/2018 - 11:51am

  10. Understanding adverse drug reactions and drug allergies: principles, diagnosis and treatment aspects.

    This 22-page open-access article published by Zahra Pourpak et al. in the Journal Recent Patents on Inflammation & Allergy Drug Discovery, describes in detail the WHO definition of adverse drug reactions (ADRs), the common features, classification according to Rawlins and Thompson and beyond. The authors also provide a comprehensive description of predictable Type A, which is dose-related pharmacological effects and the unpredictable, bizarre, Type B hypersensitivity reactions. Tables 1 and 2 detail the common examples of clinical and genetic risks of Type B ADRs.

    efaccena - 12/12/2017 - 10:28am

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