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Tubulin and microtubules as targets for anticancer drugs
Cytoskeletal targeting compounds are small molecules that interact with actin or tubulin. They can either
- stabilise cytoskeletal components
- prevent polymerisation of monomers into filaments
- enhance de-polymerisation of already formed filaments
Actin-targeting compounds have not been transferred to the clinic, but are useful experimental tools used to further understanding of how the actin machinery in cells works.
efaccena - 21/03/2016 - 1:52pm
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Drug metabolizing enzymes
Cytochrome P450 enzymes are the main drug metabolising enzymes (xenobiotic inactivators) in humans, and these are the primary contributors to Phase I oxidative metabolism of drugs and other chemicals.
efaccena - 08/03/2016 - 9:21am
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Mitotic spindle poisons
Mechanism of action
efaccena - 30/03/2023 - 2:01pm