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  1. Other autacoids

    The pharmacology and clinical impact of histamine and serotonin have been described above. This section will focus on other clinically important autacoid molecules.

    Autacoids release can be triggered by agents including chemical and immune irritants, UV light, bacterial toxins and physical trauma.

    Whilst histamine mediates the wheal, flare and redness reactions, the prostaglandins mediate pain.

    efaccena - 29/03/2016 - 1:12pm

  2. Antiplatelet drugs

    Antiplatelet drugs are designed to decrease platelet aggregation to inhibit thrombus formation in the arterial circulation. Used to treat patients with cardiac and cerebrovascular conditions.

    They are classified according to their mechanism of action:

    smaxwell - 10/10/2014 - 9:12am

  3. Ischemic heart disease

    Oxygen demand of the heart dynamically changes, and the coronary artery can adjust its blood flow to fulfill the myocardial oxygen demand (coronary blood flow reserve). Normally, the oxygen supply and the oxygen demand are well balanced in healthy subjects. When the oxygen supply to the heart becomes inadequate for the needs of the heart, myocardial ischemia occurs. That is, ischemic heart disease (IHD) is caused by an imbalance between the oxygen supply (coronary blood flow) and the oxygen demand of the heart.

    efaccena - 13/02/2018 - 10:14am

  4. Acute ischemic stroke (AIS)

    Acute ischemic stroke is caused by thrombotic or embolic occlusion of a cerebral artery, which leads to a sudden loss of blood circulation to a focal area of the brain. This results in a corresponding loss of neurologic function. The text that follows has been summarized and adapted from a transcript written by Amanda Dippold as part of her clinical pharmacology training.

    efaccena - 14/08/2018 - 10:32am