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  1. Bone resorption inhibitors

    Bisphosphonates

    Bisphosphonates are a class of drugs used to prevent loss of bone mass in conditions characterised by excessive bone resorption which causes bone fragility, such as osteoporosis, Paget's disease of bone, bone metastasis and primary hyperparathyroidism. Mechanistically bisphosphonates bind to hydroxyapatite on bony surfaces, and are taken in to osteoclasts during bone resorption. Bisphosphonates act to disrupt osteoclast function and number (via apoptosis).

    efaccena - 22/07/2016 - 8:27am

  2. Migraine

    Migraine is a complex condition, but it is characterised as a moderate to severe, pulsating headache that is typically unilateral, and is often accompanied by nausea and disturbed vision (aura). Migraines can last from two hours to several days. Associated symptoms can include nausea and vomiting, as well as sensitivities to light, sound or smell.

    Medical intervention is indicated when the migraines become frequent and/or are severe.

    efaccena - 22/05/2018 - 11:51am

  3. Gastrointestinal peptides

    The gastrointestinal hormones constitute a group of hormones secreted by enteroendocrine cells in the stomach, pancreas, and small intestine. This group of hormones regulate various functions of the digestive organs. Some of the major families are listed below.

    efaccena - 07/03/2016 - 2:08pm

  4. Endocrine peptides

    Endocrine peptides are the proteinaceous subset of the hormones produced by the glands of the endocrine system. The major endocrine glands include the pineal gland, pituitary gland, pancreas, ovaries, testes, thyroid gland, parathyroid gland, hypothalamus, gastrointestinal tract and adrenal glands. Endocrine hormones regulate a vast array of bodily functions including metabolism, growth and development, tissue function, sexual function, reproduction, sleep, and mood.

    efaccena - 07/03/2016 - 2:09pm

  5. Neurotransmitters

    Synaptic transmission relies on local synthesis, and release of neurotransmitter molecules at the synapse, binding of the neurotransmitter to its cognate post-synaptic receptor(s) and inactivation/removal of the neurotransmitter from the synaptic space to terminate the activation.

    efaccena - 29/03/2016 - 1:09pm