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Disease-modifying anti-rheumatic drugs (DMARDs)
Different types of arthritis (rheumatic disease) are treated with different drugs. The aim of the clinician is to prescribe drugs which improve symptoms and, where possible, slow or halt progress of the condition. As their name suggests, disease-modifying anti-rheumatic drugs (DMARDs) offer benefit via the latter mechanism. Full therapeutic response to DMARDs may take several months to become evident. Early intervention with DMARD therapy is recommended to control the signs and symptoms of rheumatic disease and to limit joint damage.
efaccena - 22/07/2016 - 2:10pm
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Antimetabolites
Antimetabolite drugs interfere with the synthesis of the building blocks of DNA (purine and pyrimidine bases or their corresponding nucleosides), disrupting DNA (and for some drugs RNA) synthesis and replication. Most of these drugs are structural analogues of the endogenous molecules or folate cofactors crucial for purine and pyrimidine biosynthesis. Antimetabolite class drugs principally target the de novo nucleotide synthetic pathways crucial for supplying the large nucleotide pools required by highly proliferating cancer cells.
efaccena - 16/03/2023 - 2:38pm