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Drugs affecting acetylcholine receptors
Drugs acting at ganglion nicotinic receptors
As the same receptors are present at the ganglia of both the sympathetic and parasympathetic arms of the ANS, they cannot be differentiated pharmacologically. Being ionotropic receptors, overstimulation can lead to depolarization blockade. Thus, there is the potential for both agonists and antagonists to inhibit ganglionic neurotransmission. Although ganglion blocking drugs have been used in the past in the treatment of hypertension, they are now considered clinically obsolete.
efaccena - 21/03/2016 - 10:49am
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ANS Part II: Receptors, transmitters and drugs
The two principal (or 'classical') small transmitter molecules used by neurons of the motor ANS are acetylcholine (ACh) and noradrenaline (NA).
efaccena - 01/09/2017 - 10:39am
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Drugs modifying cardiac rate and force
This 24-slide slide set provides an introduction at new learner to intermediate level to some of the most common drugs that are used clinically to modulate the rate and force of contraction of the heart. The specific drug classes presented include: agonists and antagonists of beta-adrenoceptors, an antagonist of muscarinic acetylcholine receptors (i.e. atropine), cardiotonic agents including cardiac glycosides (i.e. digoxin) and miscellaneous other agents.
efaccena - 10/07/2018 - 9:39am
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Antidiarrhoeal drugs
Antidiarrhoeal drugs are classified according to their mechanism of action:
Oral rehydration agents are used to re-balance fluid and electrolytes lost during a diarrhoeal episode. These contain defined quantities of salts and sugars to be taken with clean water.
Antibacterial agents can be used to treat diarrhea with a confirmed bacterial cause.
smaxwell - 10/10/2014 - 9:00am
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Introduction to the dose-response relationship
When the relation between drug dose (X-axis) and drug response (Y-axis) is plotted on a base 10 logarithmic scale, this produces a sigmoidal dose–response curve (Fig A). This representation is more useful than a linear plot because it expands the dose scale in the region where drug response is changing rapidly and compresses the scale at higher doses where large changes have little effect on response.
efaccena - 19/11/2015 - 9:43am
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Diarrhoea
Diarrhoea is the abnormal passing of loose or liquid stools, with increased frequency, increased volume, or both. It can be classified based on its duration into:
efaccena - 09/02/2023 - 1:44pm
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Arrhythmias
The normal heart beats regularly at 60–100 beats per min (bpm), which is controlled by the sinoatrial (SA) node located in the right atrium. Tachycardia describes a heart that beats more rapidly (>100 bpm). Bradycardia describes a situation where the heart beats more slowly (<60 bpm). Electrical signals generated in the SA node travel through a conduction pathway in the wall of the atria (causing atrial contraction) before reaching and depolarising the AV node.
efaccena - 15/03/2022 - 12:40pm