Search Page

The search found 17 results in 0.034 seconds.

Search results

  1. NSAIDs - an introduction

    This 20-slide slide set created with PowerPoint describes prostanoid synthesis and their effects on the body; mechanisms of action, beneficial and adverse effects of NSAIDS; the difference between the effects of low and high dose aspirin; and the effects and toxicity of paracetamol (acetaminophen). This is an introduction to the topic of NSAIDS which would be appropriate for beginners. Contributed by Christopher Fowler, Umeå University, Sweden.

    efaccena - 17/01/2018 - 11:20am

  2. Receptor Affinity

    Affinity of ligands is a function of both the rate of association and the rate of dissociation of the ligand–receptor complex; the former depends on the 'goodness of fit' at a molecular level, whereas the latter depends on how tightly the ligand is bound (the strength of the chemical bond). Systems requiring rapid fine modulation (e.g. nerve synapses) must have agonists with a low receptor affinity because those with high receptor affinity would produce unnecessarily prolonged responses.

    efaccena - 18/11/2015 - 3:11pm

  3. Migraine

    Migraine is a complex condition, but it is characterised as a moderate to severe, pulsating headache that is typically unilateral, and is often accompanied by nausea and disturbed vision (aura). Migraines can last from two hours to several days. Associated symptoms can include nausea and vomiting, as well as sensitivities to light, sound or smell.

    Medical intervention is indicated when the migraines become frequent and/or are severe.

    efaccena - 22/05/2018 - 11:51am

  4. secondary prevention

    Secondary prevention aims to reduce the impact of an existing disease, by detecting and treating the it as soon as possible with the aim of halting or at least slowing its progress. Examples of secondary preventions include the use of regular screening programs to detect disease at its earliest stage (e.g. breast and bowel cancer screening) and taking low-dose aspirin alongside dietary changes and exercise to prevent further heart attacks or strokes.

    efaccena - 16/03/2016 - 9:02am

  5. Thromboxane Receptors Antagonists and/or Synthase Inhibitors

    This comprehensive review discusses the pathophysiological rationale for the expected superiority of TP receptor antagonists over aspirin as anti-thrombotic agents, as well as providing an overview of the development of thromboxane receptor antagonists, and their failure to reach approval.

    efaccena - 25/03/2016 - 1:21pm

  6. Venous thromboembolism

    Venous thromboembolism (VTE) is a blood clot in a vein. VTEs can partially or completely obstruct blood flow. The most frequent types of VTE are

    • deep-vein thrombosis (DVT) and
    • pulmonary embolism (PE)

    Pharmacological VTE prophylaxis and treatment relies on the use of different classes of drugs; anti-coagulants, antiplatelet drugs and thrombolytic/fibrinolytic agents.

    efaccena - 18/04/2023 - 2:18pm

  7. Peptic ulcer disease

    Gastric and duodenal ulcers are subtypes of peptic ulcers. They are characterised by erosion of the epithelial layer of the gastric or duodenal mucosa, which causes upper abdominal pain. Less frequent symptoms include dyspepsia and nausea. Gastro-intestinal perforation and haemorrhage are serious (possibly life-threatening) complications of peptic ulcer disease.

    Two very common causes of peptic ulcer disease, which can occur independently or together, are Helicobacter pylori (H. pylori) infection and use of non-steroidal anti-inflammatory drugs (NSAIDs).

    efaccena - 06/02/2023 - 2:06pm

Pages