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  1. Theophyllines

    Theophylline is a xanthine (or methylxanthine) used as a bronchodilator indicated for asthma and chronic obstructive pulmonary disease (COPD). Theophylline is an adrenoceptor antagonist, acting primarily on the A2A and A2B adrenoceptors. Antagonism of adenosine action at these receptors results in relaxation of the smooth muscle of bronchial airways and pulmonary blood vessels.

    smaxwell - 10/10/2014 - 7:41pm

  2. Phosphodiesterase inhibitors

    Phosphodiesterases (PDEs) are enzymes responsible for the inactivation of the intracellular second messengers cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). There are many subtypes of phosphodiesterases and many inhibitors which can be either non-specific, or selective in their inhibitory profile.

    efaccena - 08/03/2016 - 9:19am

  3. Asthma

    Asthma affects 300 million people worldwide and is characterized by respiratory symptoms that burden patients and can lead to exacerbations which require medical attention and can be fatal. Common symptoms of asthma include wheezing, chest tightness, cough and shortness of breath. These symptoms are caused by inflammation and hyperreactivity in the airways leading to bronchoconstriction or airway narrowing. There are many triggers for patients with asthma including dust and allergens, pollution, cigarette smoke and even exercise or stress.

    efaccena - 11/03/2019 - 10:52am