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Heart failure
Heart failure (HF) is caused by the heart’s inability to pump enough blood to meet the body’s needs. In response, the body activates compensatory mechanisms, such as the sympathetic nervous system which leads to tachycardia, sodium and water retention, vasoconstriction, and over time, ventricular hypertrophy, all geared towards increasing cardiac output. Leading causes of HF are coronary artery disease and hypertension.
efaccena - 11/03/2019 - 11:56am
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Hypertension
Elevated blood pressure (BP) is the product of increased cardiac output (CO) and peripheral vascular resistance (PVR). Increased CO may result from increased fluid volume from excess sodium intake or renal sodium retention, stimulation of the renin-angiotensin-aldosterone system (RAAS), or activation of the sympathetic nervous system (SNS). Functional constriction or structural hypertrophy of the vasculature increases PVR. Both result from excess stimulation of the RAAS, SNS overactivity, genetic alterations of cell membranes, or endothelial-derived factors.
efaccena - 06/05/2019 - 1:49pm
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Cardiovascular peptides
Many vasoactive peptides are implicated in vascular (patho)biology.
efaccena - 07/03/2016 - 2:07pm
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Drugs acting on the kidney (3) 2017-18
This is a slide set (13 slides) covering osmotic diuretics and carbonic anhydrase inhibitors. It also discusses aldosterone and vasopression activity in the kidney, as well as the mechanism of action of SGLT2 inhibitors. The final slides discuss gout and the mechanisms employed by current anti-gout medications. It is an updated version for the 2017-18 academic year. Provided by Prof. JA Peters, University of Dundee School of Medicine.
efaccena - 10/07/2018 - 9:48am
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General overview of the RAAS system: Cells and hormones
This 15-minute animated, narrated video describes the components and pathways involved with the renin-angiotensin-aldosterone system. The role of the RAAS and its regulation of blood pressure is also discussed. Suitable for beginners.
Author: Rishi Desai, Khan Academy
efaccena - 06/05/2019 - 1:36pm
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Steroid hormones
Steroid hormones can be grouped into 2 classes: corticosteroids (typically made in the adrenal cortex) and sex steroids (typically made in the gonads or placenta).
efaccena - 29/03/2016 - 1:11pm
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Endocrine peptides
Endocrine peptides are the proteinaceous subset of the hormones produced by the glands of the endocrine system. The major endocrine glands include the pineal gland, pituitary gland, pancreas, ovaries, testes, thyroid gland, parathyroid gland, hypothalamus, gastrointestinal tract and adrenal glands. Endocrine hormones regulate a vast array of bodily functions including metabolism, growth and development, tissue function, sexual function, reproduction, sleep, and mood.
efaccena - 07/03/2016 - 2:09pm
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Angiotensin-converting enzyme (ACE) inhibitors
Angiotensin II (ATII) is a highly potent endogenous vasoconstrictor. It is formed from angiotensin I in the blood by the angiotensin converting enzyme (ACE).
smaxwell - 10/10/2014 - 9:06am
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Angiotensin receptor antagonists
Angiotensin receptor antagonists are used to treat hypertension, diabetic nephropathy and congestive heart failure. As a group these drugs are termed 'sartans', and this forms the stem of their non-proprietary names.
smaxwell - 10/10/2014 - 9:07am
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Drugs Acting on the Kidney (lecture 3)
This is a slide set covering osmotic diuretics and carbonic anhydrase inhibitors. It also discusses aldosterone and vasopression activity in the kidney, as well as the mechanism of action of SGLT2 inhibitors. The final slides discuss gout and the mechanisms employed by current anti-gout medications. Provided by Prof. JA Peters, University of Dundee School of Medicine.
efaccena - 14/03/2016 - 2:33pm