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  1. Drugs affecting cholinergic neurotransmission

    Drugs affecting synthesis, storage or release of acetylcholine

    efaccena - 21/03/2016 - 10:38am

  2. Neurotransmitters

    Synaptic transmission relies on local synthesis, and release of neurotransmitter molecules at the synapse, binding of the neurotransmitter to its cognate post-synaptic receptor(s) and inactivation/removal of the neurotransmitter from the synaptic space to terminate the activation.

    efaccena - 29/03/2016 - 1:09pm

  3. Antimuscarinic bronchodilators

    Antimuscarinic (anticholinergic) bronchodilators provide an alternative, complementary approach to the treatment of airways obstruction, to the use of beta2-adrenergic agents. They are useful for the treatment of asthmatic patients who are poorly controlled by, or who experience troublesome side-effects from, adrenergic agents.

    smaxwell - 10/10/2014 - 7:41pm

  4. ANS Part II: Receptors, transmitters and drugs

    The two principal (or 'classical') small transmitter molecules used by neurons of the motor ANS are acetylcholine (ACh) and noradrenaline (NA).

    efaccena - 01/09/2017 - 10:39am

  5. Overview of agonists and antagonists

    This approximately 4.5 minute video defines the terms agonist and antagonist using acetylcholine and curare, respectively, as examples. The video provides easy to understand definitions of the terms with a relevant example.

    efaccena - 18/11/2015 - 3:23pm

  6. The Parasympathetic Nervous System

    The parasympathetic nervous system (PNS or cholinergic system):

    Acetylcholine is the major transmitter of the parasympathetic nervous system, but is also the transmitter at the ganglia of both the sympathetic and sympathetic nervous systems and the somatic nervous system.  Cholinergic nerves are also present within the CNS.  For this reason, drugs that modulate cholinergic neurotransmission can potentially produce a range of effects. Fewer responses are achieved by using drugs which act more selectively at muscarinic or nicotinic receptors. 

    media - 23/05/2014 - 10:22am

  7. Overview of types of receptors, their mechanisms of action and examples

    Main types of drug targets and their mechanisms of action

    Drug Target

    Description

    Example(s)

    Receptors

    Channel-linked receptors

    media - 22/05/2014 - 12:09pm

  8. Anti-emetic drugs

    Drug-induced emesis can now be largely controlled with anti-emetic drugs, however, nausea remains a very significant clinical problem. This dichotomy suggests that different mechanisms underlie nausea and vomiting.

    smaxwell - 10/10/2014 - 7:50pm

  9. Drugs modifying cardiac rate and force

    This 24-slide slide set provides an introduction at new learner to intermediate level to some of the most common drugs that are used clinically to modulate the rate and force of contraction of the heart. The specific drug classes presented include: agonists and antagonists of beta-adrenoceptors, an antagonist of muscarinic acetylcholine receptors (i.e. atropine), cardiotonic agents including cardiac glycosides (i.e. digoxin) and miscellaneous other agents.

    efaccena - 10/07/2018 - 9:39am

  10. Ligand-gated ion channels

    Ligand-gated ion channels (LGICs) mediate passive ion flux driven by the electrochemical gradient for the permeant ions. LGICs are gated by the binding of a specific ligand to an orthosteric site(s) that triggers a conformational change that results in the conducting state, or by binding of endogenous, or exogenous, modulators to allosteric sites. LGICs are responsible for fast synaptic transmission in the nervous system and at the somatic neuromuscular junction.

    efaccena - 24/02/2016 - 3:56pm

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