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  1. T-cell activation inhibitors (under construction)

    T-cell activation inhibitors are immunosuppressants. They find clinical use in autoimmune disease and transplant rejection prevention.

    efaccena - 12/09/2016 - 10:36am

  2. Biological DMARDs

    Biological DMARDs take the form of monoclonal antibodies (mAbs) and recombinant fusion proteins which modulate cytokine levels via mechanisms which inhibit T and B cell activation, or by directly inhibiting pro-inflammatory tumour necrosis factor alpha (TNFα). All cytokine modulators must be used under specialist supervision.

    Examples currently employed for anti-rheumatic therapy include:

    efaccena - 25/07/2016 - 2:22pm

  3. Disease-modifying anti-rheumatic drugs (DMARDs)

    Different types of arthritis (rheumatic disease) are treated with different drugs. The aim of the clinician is to prescribe drugs which improve symptoms and, where possible, slow or halt progress of the condition. As their name suggests, disease-modifying anti-rheumatic drugs (DMARDs) offer benefit via the latter mechanism. Full therapeutic response to DMARDs may take several months to become evident. Early intervention with DMARD therapy is recommended to control the signs and symptoms of rheumatic disease and to limit joint damage.

    efaccena - 22/07/2016 - 2:10pm

  4. Immuno-oncology

    Immune Checkpoint inhibitors

    efaccena - 06/09/2022 - 2:03pm