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1. Antimetabolites

   Antimetabolite drugs interfere with the synthesis of the building blocks of DNA (purine and pyrimidine bases or their corresponding nucleosides), disrupting DNA (and for some drugs RNA) synthesis and replication. Most of these drugs are structural analogues of the endogenous molecules or folate cofactors crucial for purine and pyrimidine biosynthesis. Antimetabolite class drugs principally target the de novo nucleotide synthetic pathways crucial for supplying the large nucleotide pools required by highly proliferating cancer cells.

   efaccena - 16/03/2023 - 2:38pm

2. Therapy optimization

   Patients with a given disease may differ dramatically in the desired and undesired effects of one and the same standard drug therapy. Extreme examples are:

   efaccena - 24/03/2016 - 9:43am