Opthalmic Prostaglandin Analogs

For the treatment of glaucoma

Prostaglandin Analogs attenuate intraocular pressure (IOP) by improving the outflow of aqueous humor. Prostaglandin analogs exhibit agonistic activity on FP prostanoid receptors, which promotes uveoscleral outflow. Medications within this class include latanoprost, travoprost, bimatoprost, tafluprost, and unoprostone isopropyl. These topical medications offer the greatest reduction in IOP. Prostaglandin analogs can cause undesirable cosmetic changes such as brown pigmentation of the iris, discoloration of the eyelids, and increased growth/thickness of eyelashes. Other adverse effects include blurred vision, eye irritation, itching, and headache.