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1. Leukotriene receptor antagonists

   Leukotriene receptor antagonists (LTRAs) block the action of leukotriene D4 (and to a lesser extent leukotrienes C₄ and E₄) on the cysteinyl leukotriene receptor CysLT₁ in the lungs and bronchial tubes. This action reduces the inflammatory bronchoconstriction caused by leukotriene. LTRAs are not suitable for treating acute asthma attacks. They do not interact with theophyllines, as they operate by different molecular mechanisms.

   smaxwell - 10/10/2014 - 7:43pm

2. Other autacoids

   

   The pharmacology and clinical impact of histamine and serotonin have been described above. This section will focus on other clinically important autacoid molecules.

   Autacoids release can be triggered by agents including chemical and immune irritants, UV light, bacterial toxins and physical trauma.

   Whilst histamine mediates the wheal, flare and redness reactions, the prostaglandins mediate pain.

   efaccena - 29/03/2016 - 1:12pm