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  1. Antisecretory drugs

    In the gastrointestinal system, anti-secretory drugs are used to decrease acid secretion in the stomach.

    Drug families include:

    Histamine H2 receptor antagonists are used to treat functional dyspepsia and to promote healing of NSAID-associated ulcers e.g. cimetidine and famotidine.

    smaxwell - 10/10/2014 - 9:01am

  2. Peptic ulcer disease

    Gastric and duodenal ulcers are subtypes of peptic ulcers. They are characterised by erosion of the epithelial layer of the gastric or duodenal mucosa, which causes upper abdominal pain. Less frequent symptoms include dyspepsia and nausea. Gastro-intestinal perforation and haemorrhage are serious (possibly life-threatening) complications of peptic ulcer disease.

    Two very common causes of peptic ulcer disease, which can occur independently or together, are Helicobacter pylori (H. pylori) infection and use of non-steroidal anti-inflammatory drugs (NSAIDs).

    efaccena - 06/02/2023 - 2:06pm

  3. Gastro-oesophageal reflux disease (GORD)

    Gastro-oesophageal reflux disease (GORD; also known as GERD Gastro-esophageal reflux disease)

    efaccena - 06/02/2023 - 1:40pm

  4. Voltage-gated ion channels

    Voltage-gated ion channels (VGICs) are responsive to changes in the local electrical membrane potential, and are critical for the function of excitable cells, such as neurons and muscle cells. VGICs are ion-selective, with separate channels identified for each of the major physiological ions- Na+, K+, Ca2+, Cl-. Each type of channel is a multimeric complex of subunits encoded by a number of genes. Subunit combinations vary in different tissues, with each combination having distinctive voltage dependence and cellular localization.

    efaccena - 24/02/2016 - 3:26pm