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1. Anticonvulsant drugs

   Anticonvulsants drugs can be classified according to their molecular mechanism of action. In general, the most useful mechanisms exploited therapeutically are those that enhance gamma-aminobutyric acid (GABA) action and inhibit sodium channel activity. Other mechanisms include inhibition of calcium channels and glutamate receptors.

   smaxwell - 10/10/2014 - 7:48pm

2. Generalised anxiety disorder (GAD)

   GAD is one of the most commonly diagnosed mental health disorders and its symptoms and consequences put pressure on both general practice and emergency departments. It is generally defined as chronic, excessive worry lasting more than six months which is having a disruptive impact on a person’s life. GAD does not include anxiety that is part of another mental health disorder, a result of substance misuse or another health condition (e.g. hyperthyroidism). However, it often occurs in association with major depression.

   efaccena - 05/06/2023 - 11:35am

3. Ligand-gated ion channels

   Ligand-gated ion channels (LGICs) mediate passive ion flux driven by the electrochemical gradient for the permeant ions. LGICs are gated by the binding of a specific ligand to an orthosteric site(s) that triggers a conformational change that results in the conducting state, or by binding of endogenous, or exogenous, modulators to allosteric sites. LGICs are responsible for fast synaptic transmission in the nervous system and at the somatic neuromuscular junction.

   efaccena - 24/02/2016 - 3:56pm