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  1. Antisecretory drugs

    In the gastrointestinal system, anti-secretory drugs are used to decrease acid secretion in the stomach.

    Drug families include:

    smaxwell - 10/10/2014 - 9:01am

  2. Cyclooxygenase (COX) inhibitors

    Cyclooxygenase (COX) inhibitors are non-steroidal anti-inflammatory drugs (NSAIDs), used clinically to relieve fever and pain, such as those associated with headaches, colds, flu, and arthritis. NSAIDs are available by prescription and over-the-counter (OTC).

    efaccena - 08/03/2016 - 9:19am

  3. NSAIDs for musculoskeletal conditions

    There are about 20 different nonsteroidal anti-inflammatory drugs (NSAIDs) available. Some, such as aspirin and ibuprofen, are widely available over-the-counter (OTC). Others are only available on prescription. NSAIDs are the most frequently used medicines for symptomatic relief in osteoarthritis (OA), the most common form of arthritis, and are often prescribed to rheumatoid arthritis (RA) patients.

    efaccena - 22/07/2016 - 8:25am

  4. Drug metabolizing enzymes

    Cytochrome P450 enzymes are the main drug metabolising enzymes (xenobiotic inactivators) in humans, and these are the primary contributors to Phase I oxidative metabolism of drugs and other chemicals.

    efaccena - 08/03/2016 - 9:21am

  5. Introduction to the dose-response relationship

    When the relation between drug dose (X-axis) and drug response (Y-axis) is plotted on a base 10 logarithmic scale, this produces a sigmoidal dose–response curve (Fig A). This representation is more useful than a linear plot because it expands the dose scale in the region where drug response is changing rapidly and compresses the scale at higher doses where large changes have little effect on response.

    efaccena - 19/11/2015 - 9:43am

  6. Voltage-gated ion channels

    Voltage-gated ion channels (VGICs) are responsive to changes in the local electrical membrane potential, and are critical for the function of excitable cells, such as neurons and muscle cells. VGICs are ion-selective, with separate channels identified for each of the major physiological ions- Na+, K+, Ca2+, Cl-. Each type of channel is a multimeric complex of subunits encoded by a number of genes. Subunit combinations vary in different tissues, with each combination having distinctive voltage dependence and cellular localization.

    efaccena - 24/02/2016 - 3:26pm