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1. Tubulin and microtubules as targets for anticancer drugs

   Cytoskeletal targeting compounds are small molecules that interact with actin or tubulin. They can either

   • stabilise cytoskeletal components
   • prevent polymerisation of monomers into filaments
   • enhance de-polymerisation of already formed filaments

   Actin-targeting compounds have not been transferred to the clinic, but are useful experimental tools used to further understanding of how the actin machinery in cells works.

   efaccena - 21/03/2016 - 1:52pm