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  1. Neurotransmitters

    Synaptic transmission relies on local synthesis, and release of neurotransmitter molecules at the synapse, binding of the neurotransmitter to its cognate post-synaptic receptor(s) and inactivation/removal of the neurotransmitter from the synaptic space to terminate the activation.

    efaccena - 29/03/2016 - 1:09pm

  2. Parkinson’s disease

    Parkinson's disease is an incurable, progressive neurodegenerative condition that is characterised by the loss of dopaminergic neurons in the substantia nigra. The disease presents with a range of

    efaccena - 20/06/2023 - 9:18am

  3. Levodopa

    Levodopa (L-DOPA) is the amino-acid precursor of the neurotransmitter dopamine, used in the treatment of Parkinson's disease. Administration of levodopa aims to restore dopamine levels which are significantly reduced in Parkinson's patients. Levodopa has the advantage over dopamine that it can cross the blood-brain barrier, whereas dopamine cannot.

    smaxwell - 10/10/2014 - 7:45pm

  4. Drugs used to manage schizophrenia

    Schizophrenia is a disorder of the mind that is debilitating and chronic. The prevalence of this disorder is about 1% of the population and seems to affect all areas of the globe equally. It is not well understood what causes the disorder.

    efaccena - 20/05/2019 - 1:03pm

  5. Other antiparkinsonian drugs

    Dopamine-receptor agonists

    smaxwell - 10/10/2014 - 7:47pm

  6. Transporters as drug targets, and drug interactions

    Monoamine reuptake transporters

    efaccena - 21/03/2016 - 1:57pm

  7. Antipsychotic drugs

    Antipsychotic use is associated with significant side-effects, most notably movement disorders (tardive dyskinesia) and weight gain. It is unclear whether the atypical (second-generation) antipsychotics offer advantages over older, first generation antipsychotics. Drop-out and symptom relapse rates are similar for both classes of drugs.

    Both generations of medication block receptors in the brain's dopamine pathways, but atypical antipsychotics often act on serotonin receptors as well.

    smaxwell - 10/10/2014 - 7:56pm

  8. Anti-emetic drugs

    Drug-induced emesis can now be largely controlled with anti-emetic drugs, however, nausea remains a very significant clinical problem. This dichotomy suggests that different mechanisms underlie nausea and vomiting.

    smaxwell - 10/10/2014 - 7:50pm

  9. Endocrine peptides

    Endocrine peptides are the proteinaceous subset of the hormones produced by the glands of the endocrine system. The major endocrine glands include the pineal gland, pituitary gland, pancreas, ovaries, testes, thyroid gland, parathyroid gland, hypothalamus, gastrointestinal tract and adrenal glands. Endocrine hormones regulate a vast array of bodily functions including metabolism, growth and development, tissue function, sexual function, reproduction, sleep, and mood.

    efaccena - 07/03/2016 - 2:09pm

  10. Depression

    Depression (major depressive disorder) is a mood disorder characterised by low mood which persists for weeks or months and has a significant impact on daily life. It is a common disorder and the WHO estimates that around 5% of adults globally are affected.

    Aetiology

    efaccena - 05/06/2023 - 12:55pm

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