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  1. Muscle relaxants

    Muscle relaxants are a group drugs that act as central nervous system depressants which have overall sedative and musculoskeletal relaxant properties. Examples from many different drug classes have these effects, despite their different mechanisms of action. Muscle relaxants should preferably be prescribed short-term to reduce skeletal muscle spasms, provide relief from pain, and increase mobility of the affected muscles and should where appropriate be used together with rest and physical therapy as part of an overall recovery strategy.

    efaccena - 22/07/2016 - 8:28am

  2. Drug interactions - Distribution

    Distribution interactions occur when drugs are extensively protein-bound and the co-administration of a second can displace it to the non-bound active form. This increases the amount of (unbound) drug available to cause an effect. For example, diazepam displaces phenytoin from plasma proteins, resulting in an increased plasma concentration of free phenytoin and an increased risk of toxicity. The effects of protein displacement are usually short-lived because the metabolism of the affected drug usually increases in parallel with the increased free drug concentration.

    smaxwell - 30/12/2015 - 10:31am

  3. Anticonvulsant drugs

    Anticonvulsants drugs can be classified according to their molecular mechanism of action. In general, the most useful mechanisms exploited therapeutically are those that enhance gamma-aminobutyric acid (GABA) action and inhibit sodium channel activity. Other mechanisms include inhibition of calcium channels and glutamate receptors.

    smaxwell - 10/10/2014 - 7:48pm

  4. Hypnotic and anxiolytic drugs

    The pharmacology of drugs with anxiolytic, sedative, and hypnotic effects overlaps significantly, with different doses of the same drug having effects ranging from sedation to loss of consciousness. So it can be difficult to ascribe just one function to each drug. The job of the prescriber is to identify the drug which offers the best therapeutic outcome for their patient.

    smaxwell - 10/10/2014 - 7:53pm

  5. Generalised anxiety disorder (GAD)

    GAD is one of the most commonly diagnosed mental health disorders and its symptoms and consequences put pressure on both general practice and emergency departments. It is generally defined as chronic, excessive worry lasting more than six months which is having a disruptive impact on a person’s life. GAD does not include anxiety that is part of another mental health disorder, a result of substance misuse or another health condition (e.g. hyperthyroidism). However, it often occurs in association with major depression.

    efaccena - 05/06/2023 - 11:35am