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  1. Alkylating Agents: Nitrogen mustard derivatives

    Several alkylating agents are used in clinical practice. They all share the same mechanism of action; they introduce alkyl groups into nucleophilic sites on other molecules, DNA being the principal target in cancers.  Alkylating agents can be subdivided into chemical classes, one of which is the nitrogen mustard derivatives.

    efaccena - 16/03/2023 - 12:36pm

  2. Alkylating chemotherapy agents

    Alkylating agents were one of the earliest classes of drugs used to treat cancer. They disrupt DNA structure and formation to cause irreparable DNA damage in cancer cells which ultimately leads to cell death.

    The five major categories of alkylating agents are:

    efaccena - 21/03/2016 - 3:36pm

  3. Drug metabolizing enzymes

    Cytochrome P450 enzymes are the main drug metabolising enzymes (xenobiotic inactivators) in humans, and these are the primary contributors to Phase I oxidative metabolism of drugs and other chemicals.

    efaccena - 08/03/2016 - 9:21am

  4. Disease-modifying anti-rheumatic drugs (DMARDs)

    Different types of arthritis (rheumatic disease) are treated with different drugs. The aim of the clinician is to prescribe drugs which improve symptoms and, where possible, slow or halt progress of the condition. As their name suggests, disease-modifying anti-rheumatic drugs (DMARDs) offer benefit via the latter mechanism. Full therapeutic response to DMARDs may take several months to become evident. Early intervention with DMARD therapy is recommended to control the signs and symptoms of rheumatic disease and to limit joint damage.

    efaccena - 22/07/2016 - 2:10pm