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1. Bone resorption inhibitors

   Bisphosphonates

   Bisphosphonates are a class of drugs used to prevent loss of bone mass in conditions characterised by excessive bone resorption which causes bone fragility, such as osteoporosis, Paget's disease of bone, bone metastasis and primary hyperparathyroidism. Mechanistically bisphosphonates bind to hydroxyapatite on bony surfaces, and are taken in to osteoclasts during bone resorption. Bisphosphonates act to disrupt osteoclast function and number (via apoptosis).

   efaccena - 22/07/2016 - 8:27am

2. Renal osteodystrophy (bone disease)

   Bone health is regulated by several inter-connected pathways:

   efaccena - 29/05/2023 - 2:03pm