Population genetic effects on pharmacogenomic diversity: warfarin in a Brazilian cohort

This slide set examines the impact of population admixture on global pharmacogenomic diversity, using data from the highly heterogeneous and admixed Brazilian population.  Results obtained with ancestry-informative markers are presented  and discussed in relation to the the tri-hybrid – Amerindian, European and African – biogeographical ancestry of Brazilians.  Links to  databases on the distribution of pharmacogenomic polymorphisms among Brazilians are provided.  The challenges and opportunities  for pharmacogenomics research and clinical implementation  in  admixed populations are explore