Paracetamol (acetaminophen) and other simple analgesics

Paracetamol (acetaminophen) and other simple analgesics

Paracetamol (acetaminophen) is not classed as an NSAID because it lacks anti-inflammatory activity and only weakly inhibits COX isoenzymes. The analgesic effect of paracetamol may involve its metabolites (e.g. N-acetyl-p-benzoquinoneimine, which is also responsible for hepatotoxicity in overdosage). TRPA1 (an excitatory cation-selective ion channel) has emerged as a recent, novel, target that is activated by such metabolites (Gentry et al., 2015), as has the capsaicin receptor TRPV1 (Eberhardt et al., 2017).

Mechanisms of analgesia 2017_2018

This set of 17 slides introduces students (beginner to intermediate learners) to some of the basic physiological processes that are the targets of many analgesic drug classes. Specific areas covered include the regulation of nociceptive input to the spinal cord by processes within the superficial layers of the cord itself and also descending fibres from the brainstem.

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