Opthalmic Parasympathomimetic Agents

For the treatment of glaucoma

Parasympathomimetic Agents are topical cholinergic agonists that reduce IOP by improving fluid outflow through the trabecular meshwork. Activation of muscarinic (M₃) receptors allows for contraction of ciliary muscle fibers, which expands the pores of the trabecular meshwork to enhance outflow. Ophthalmic agents within this class include carbachol and pilocarpine. Adverse effects include sweating, salivation, eye pain, blurred vision, abdominal pain, and headache. Parasympathomimetics are contraindicated in those with uncontrolled asthma